The DNMT3B Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DNMT3B, and ICF1. This antibody recognizes Human antigen. The DNMT3B Antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing By similarity. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.Deloukas P., Nature 414:865-871(2001).Li H., J. Biol. Chem. 281:19489-19500(2006).Wijmenga C., Hum. Mutat. 16:509-517(2000)